Side Effects of Oxymetholone

The side effects of Oxymetholone can be vast despite it being an extremely beneficial steroid. When it comes to the side effects of Oxymetholone, we have a bit of an anomaly when we compare it to many other steroids. Oxymetholone does not follow the same rules of most steroids when it comes to direct effects. Further, this is a steroid that carries numerous possible adverse reactions, and as a result responsible use is even more important with this steroid. It is extremely easy for the side effects of Oxymetholone to get out of control if responsible practices are not followed. However, responsible use is extremely easy to follow, and as a result the side effects can be very easy to avoid. If this safe use is to be achieved, before use begins there is an important checklist of requirements that must be met each and every time:

  • You DO NOT suffer from high blood pressure
  • You DO NOT suffer from high cholesterol
  • You DO NOT suffer from prostate enlargement
  • You DO NOT have any liver issues

You DO NOT rely on numerous OTC or Prescription meds

  • You are NOT a heavy drinker
  • You are a healthy adult male

Estrogenic Side Effects of Oxymetholone:

Oxymetholone is a dihydrotestosterone (DHT) derived anabolic steroid, and like all DHT compounds it does not aromatize; aromatization referring to the conversion of testosterone to estrogen. Even so, Oxymetholone carries a strong estrogenic nature and as a result the related side effects. How estrogenic is it? It's about as strong as a steroid can be, and this will make issues such as gynecomastia and water retention a strong concern. As direct aromatase activity is not the culprit, often certain AI's will not work, it won't be enough for some men, but most men will find an AI to be effective. If it's not, if the estrogenic side effects of Oxymetholone are still prevalent this probably means the steroid isn't for you.


For most men, some type of AI is highly recommended if the estrogenic side effects of Oxymetholone are to be controlled. In most cases, Letrozole (Femara) should be your choice, as it will work best with this steroid. Further, this will help with water retention, and in turn help with high blood pressure that can occur due to water retention; in-fact, related high blood pressure is quite common if proper steps are not followed. Obviously an AI will help since they reduce estrogen levels and excess estrogen is the prime culprit of water retention, but there's more to say. A healthy diet is extremely important and part of a healthy diet means not gorging; this is especially important as it pertains to carbohydrates. If you gorge and eat far more than you need, you're going to hold water with or without an AI, not to mention gain a lot of body fat. If the estrogenic side effects of Oxymetholone are to be controlled, the use of an AI and an overall healthy lifestyle will be your primary tools of defense.

DHT Side Effects of Oxymetholone:

As a DHT derived anabolic steroid, it's no surprise androgenic related side effects can occur. Such side effects of Oxymetholone include acne, hair loss and prostate enlargement. Acne will be the most common of such effects, and by far the easiest to control. By keeping the skin clean and dry at all times most won't have a problem, but those who are extremely acne sensitive may need to seek out dermatological treatment. When it comes to hair loss, this is only a risk for those predisposed to male pattern baldness, and due to the nature of this steroid it's unlikely 5-alpha reductase inhibitors will offer any protection. If you are predisposed to male pattern baldness and concerned about your hairline you'll want to avoid this steroid. As for prostate enlargement, while possible it is highly unlikely unless massive doses are used for long periods of time. It is still important you keep an eye on your prostate should an underlying issue exist. As you can see, the side effects of Oxymetholone in this related category will be more response based than anything else.

Hepatotoxic Side Effects of Oxymetholone:

Oxymetholone is a C71-alpha alkylated (C17-aa) steroid, a label that refers to a structural change of the hormone at the 17th carbon position. By this structural change, the hormone is enabled with the ability to survive ingestion; without the change it would be destroyed by the liver. Unfortunately, this necessary structural change also makes the hormone toxic to the liver, and of all the hepatotoxic steroids Oxymetholone is one of the strongest.

With the use of Oxymetholone, liver enzyme values will increase, and it is quite possible for long-term use to lead to liver damage. Remember, an increase in liver enzymes does not equate to damage, but it is an indicator and will occur if levels remain high for long periods of time. For this reason, it is imperative total use of this steroid is short lived; six weeks max with four often begin optimal. Further, there should be at least six weeks of no C17-aa steroid use in-between periods of use with twelve weeks being optimal.

Maintaining proper doses is imperative, but those who are going to protect themselves from the hepatotoxic side effects of Oxymetholone will find a few important rules to exist. It is imperative you avoid excess alcohol consumption as this will burden the liver greatly; in-fact, it would be best to avoid all alcohol consumption. Alcohol does nothing to improve performance, the very reason most will use this steroid; alcohol may be in many ways the most anti-performance substance we can put in our body. Further, those who use this steroid must avoid all over the counter medications when possible. Many OTC medications are just as if not more toxic to the liver than many anabolic steroids, and use must be limited to when only absolutely necessary if we are to remain healthy.

Testosterone Side Effects of Oxymetholone:

Oxymetholone will suppress your natural testosterone production, and as a result lead to testicular atrophy. While these are guaranteed side effects of Oxymetholone, they are of no concern so as long as we provide our body with exogenous testosterone while using Oxymetholone. Further, once use is discontinued and all the exogenous hormones have cleared your system, your natural testosterone production will begin again and your testicles will return to their normal size. It should be noted; testicular atrophy refers to a loss of fullness, not vanishing. It should also be noted; natural testosterone recovery assumes no previous low testosterone condition or severe damage to the HPTA during use with improper practices.